This week saw us celebrate World Blood Donor Day, an international celebration of the
miracle of blood donation and transfusion. The theme for this year was the idea
that ‘blood connects us all’. In this week’s blog Alice examines how that
sentiment was quite literal in the early days of blood transfusion, and how the celebration of donors plays a central role...
When we consider what an
integral role blood transfusion plays in modern medicine, it’s surprisingly to think about how new the practice is. Although interest in the idea is evident as far back as the 17th century,
it wasn’t until the late 19th century that practitioners began to experiment
with it in a more serious way.
There were a number of factors
that made blood transfusion a fairly impossible procedure to carry out. Firstly,
it wasn’t until Karl Landsteiner identified the different blood groups in 1900 that
the interactions between these blood types were understood. He established that
if a transfusion of an incompatible blood type is given, there can be fatal
consequences as the two sets of cells attack each other. Landsteiner’s
discovery minimised this risk.
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Andrew Crosbie demonstrating sterilization methods [GD14A/4/12] |
A second barrier to blood
transfusion becoming an established procedure was the problem of finding a
suitable donor. With no central register of donors this had to be done on a
patient-by-patient basis, and often family members and friends were asked
first. Even if a compatible donor was found, they would then have to be brought
to the patient’s side – quite literally, that is, for the biggest barrier to
successful transfusions was that of clotting. In modern medicine,
anticoagulants are added to blood to prevent clotting and allow blood to be
stored and transported, but earlier problem-solvers took a much more hands-on
approach. Donor and recipient would have to lie alongside one another, with the
donor’s “left arm grasping the patient’s left arm well above the elbow”, and
the giving and receiving veins actually stitched together. This must have been
a very distressing experience for all involved, not least impractical and
dangerous, and early blood donors would probably understand more than most the
sentiment behind ‘blood connects us all’…
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Donors in the Clinical Laboratory being supervised by Dr McRae (Director) and Miss Wilkinson. [GD14A/4/6] |
Thankfully, huge leaps forward were
to be made over the years: swift transfers using syringes went some way towards
progress, and wax-lined containers such as the ‘Kimpton tube’ reduced the need
for donor and recipient to be in the same room together. Clotting remained very
much an issue, however, and as there was still no possibility of the blood
banks that we know, finding available and compatible donors was a huge problem.
Local attempts to mitigate this
began with a man called J. R. Copland. In January 1930, horrified to learn that
a friend’s wife had died because no blood donor could be found in time, Copland
made the first moves towards establishing a register of donors who could be
relied upon in times of need. Copland managed to enlist twenty-four individuals
within two months but this was not nearly enough. There were still too many
instances when donors could not be fetched in time, and medical staff and
students of the Royal Infirmary of Edinburgh had to step in often instead.
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J.R. Copland [GD14A/3/20] |
Some of these students had already
recognised the need for a register of donors and made their own attempts to
address this. Also in January 1930, three of them – D.M. Blair, A. Desmond
Stoker and W.I.C. Morris – proposed to establish a group of donors specifically
to be called upon by the RIE, and initially managed to recruit about eighteen
individuals, mostly other students. This group ran for about two years before
the students graduated and moved away, resulting in dwindling numbers of
donors.
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From the Minutes of the Board of Management of the RIE. [LHB1/1/64] |
Both A Desmond Stoker and J.R.
Copland embodied a central tenant of the donor system as we have it now. Stoker
was Type 0, considered a ‘universal’ donor and able to give his blood to any recipient
without adverse reaction He gave ten pints of blood before being warned by
other medical professionals of the potential harm he was causing himself!
Similarly, in one report of his service, Copland reported that “one organiser”
(most likely Copland himself) “has given fourteen pints”. Both men were of the
opinion that blood donation should be an act of charity, with blood offered and
received freely. When a meeting was called in June 1936 to establish a centralised
Blood Transfusion Service “in order that this important work might be carried
on in future”, the question was raised of whether donors should be paid for their
service. This was rejected, and the idea that donations “should be the free
will offering of men who love their fellow mortals” was heartily expressed.
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Publicity posters. [GD14/14/13/2] |
That is not to say, however, that
this gift has gone unappreciated. The letters of thanks received by
the service demonstrate the gratitude and indebtedness that both recipients and
their family have felt throughout the years. As the writer of this particular
letter remarks, “I know that all donors give their services for the benefit of
others and without thought of thanks or reward: but I cannot help thinking that
the knowledge of the recovery they have helped to bring about must be a
pleasure to them”.
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A letter of thanks written to a donor, in J.R. Copland's correspondence files. [GD14/11/2] |
Recognising the unique gift that donors
offer has always played a crucial part in the operation of the service, as can
be seen the issuing of badges to commemorate milestone donations. World Blood
Donor Day gives us another opportunity to celebrate donors and their
contribution to modern medicine.
You can find out more about registering as a blood donor on the Scottish National Blood Transfusion Association website.
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Sources
Masson, A. H. B. (1985). History of the Blood Transfusion Service in Edinburgh.